Formulation and Evaluation of Mouth Dissolving Tablets of Montelukast sodium

The present study aims to formulate mouth dissolving tablets of montelukast sodium by direct compression method for the faster action, better absorption and improvement bioavailability drug in management Asthma. Total six formulations were developed with varying concentrations combination Crosspovidone Sodium starch glycolate as super disintegrating agents. prepared method. MDT evaluated various parameters i.e. shape size, weight variation, thickness, hardness, friability, wetting time, disintegration content, dissolution test, accelerated stability studies etc. After comparing results (particularly time profile), it was concluded that formulation TF3 selected best among all.
 Keywords: Montelukast sodium, Mouth Dissolving Tablets, Direct Compression, in-vitro dissolution.